Research Articles about Prolotherapy and Regenerative Medicine.

Reviews of the Evidence:

• Myths and Facts of In-Office Regenerative Procedures for Tendinopathy
• Past, Current and Future Interventional Orthobiologics Techniques and How They Relate to Regenerative Rehabilitation

Prolotherapy Effects on:

Knee Osteoarthritis

• Dextrose prolotherapy for knee osteoarthritis
• Efficacy of Intra-Articular Hypertonic Dextrose(Prolotherapy) for Knee Osteoarthritis
• Hypertonic dextrose injections (prolotherapy) in the treatment of symptomatic knee osteoarthritis:
• Chondrogenic Effect of Intra‐articular Hypertonic‐Dextrose (Prolotherapy) in Severe Knee Osteoarthritis

Rotator Cuff Tendinopathy

• Effectiveness of prolotherapy in the treatment of chronic rotator cuff lesions
• Effects of hypertonic dextrose injection in chronic supraspinatus tendinopathy of the shoulder
• Dextrose Prolotherapy Versus Control Injections in Painful Rotator Cuff Tendinopathy

Temporomandibular Joint Dysfunction

• The efficacy of dextrose prolotherapy over placebo for temporomandibular joint hypermobility
• Long-term therapeutic effects of dextrose prolotherapy in patients with hypermobility of the temporomandibular joint
• Evaluation of prolotherapy in comparison with occlusal splints in treating internal derangement of the temporomandibular joint

Patella Tendinopathy

• Ultrasound-guided injections of hyperosmolar dextrose for overuse patellar tendinopathy

Osgood Schlatters

• Hyperosmolar dextrose injection for recalcitrant Osgood-Schlatter disease

Tennis Elbow (Lateral epicondylitis)

• Prolotherapy injections and physiotherapy used singly and in combination for lateral epicondylalgia
• Hypertonic dextrose and morrhuate sodium injections (prolotherapy) for lateral epicondylosis (tennis elbow) 

Acromioclavicular Joint and Acromial Enthesopathy

• Ultrasound-Guided Prolotherapy for Acromial Enthesopathy and Acromioclavicular Joint Arthropathy

Achilles Tendinopathy

• Prolotherapy injections and eccentric loading exercises for painful Achilles tendinosis
• Prolotherapy injections and eccentric loading exercises for painful Achilles tendinosis
• Sonographically guided intratendinous injection of hyperosmolar dextrose to treat chronic tendinosis of the Achilles tendon

Chronic Groin Pain (Adductor Tendinopathy and Osteitis Pubis)

• Efficacy of dextrose prolotherapy in elite male kicking-sport athletes with chronic groin pain

Plantar Fasciitis

• Effect of Dextrose Prolotherapy on Pain Intensity, Disability, and Plantar Fascia Thickness in Unilateral Plantar Fasciitis
• Autologous platelet-rich plasma versus dextrose prolotherapy for the treatment of chronic recalcitrant plantar fasciitis

Secondary Osteoarthritis of the Hip due to Developmental Dysplasia of Hip (DDP)

• Treatment of Osteoarthritis Secondary to Developmental Dysplasia of the Hip with Prolotherapy Injection versus a Supervised Progressive Exercise Control

Osteoarthritic Thumb, Fingers

• Randomized, prospective, placebo-controlled double-blind study of dextrose prolotherapy for osteoarthritic thumb and finger (DIP, PIP, and trapeziometacarpal) joints: evidence of clinical efficacy
• Hypertonic dextrose versus corticosteroid local injection for the treatment of osteoarthritis in the first carpometacarpal joint

Sacroiliac Joints

• The use of prolotherapy in the sacroiliac joint
• Functional outcome from sacroiliac joint prolotherapy in patients with sacroiliac joint instability